Michelle Y. Y. Lee

A reasoning LLM combining ESM3 embeddings with GO-GPT term predictions produces protein function annotations that experts rated tie-or-better than UniProt in 79% of cases (SFT model).

The paper identifies transitional cell states between alpha and beta cells in human islets using single-cell multiome data, suggesting potential for alpha-to-beta transdifferentiation.

This study identifies G6PC2's role in regulating glucagon secretion in α-cells, showing it controls glucose setpoint and suggests G6PC2 inhibitors could improve glycemic control.

This study benchmarks seven methods for integrating unpaired and paired scRNA-seq and snATAC-seq data, finding that multiome data improve cell type annotation but require sufficient cell numbers.

This study uses imaging mass cytometry to analyze pancreatic cells in T2D patients and controls, revealing changes in islet structure, cell composition, and immune cell infiltration.

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

This study profiles single-cell transcriptomes of mouse and hESC-derived endocrine progenitors to identify markers and cell-state populations relevant to beta-cell formation.