Vivek Rao

This paper validates a THP-1 macrophage model with Mycobacterium marinum for rapid screening of intracellular antimycobacterial compounds, identifying phenothiazines as effective adjuncts to TB therapy.

This paper shows sertraline enhances macrophage bactericidal activity against Mtb by rewiring cholesterol metabolism and activating inflammasome pathways.

The paper investigates how sertraline enhances TB drug efficacy by modulating macrophage mitochondrial physiology and inflammasome activation.

This study evaluates the COVIDSeq protocol for SARS-CoV-2 detection and genetic epidemiology, showing high concordance with RT-PCR and identifying novel variants and lineages.

The paper identifies a mutation in the papA2 gene of Mycobacterium tuberculosis that leads to loss of sulfolipids by disrupting protein stability and structure.