Kanika Bisht

This paper validates a THP-1 macrophage model with Mycobacterium marinum for rapid screening of intracellular antimycobacterial compounds, identifying phenothiazines as effective adjuncts to TB therapy.

This paper shows sertraline enhances macrophage bactericidal activity against Mtb by rewiring cholesterol metabolism and activating inflammasome pathways.

This study shows sertraline improves bacterial control in TB models by enhancing the pharmacodynamic-pharmacokinetic properties of TB drugs without altering their distribution or clearance.

The paper investigates how sertraline enhances TB drug efficacy by modulating macrophage mitochondrial physiology and inflammasome activation.