Author

David Häckes

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)ORCID 0000-0002-2177-5206Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Katjana SchwabiD· 2 shared Konstantin RiegeiD· 2 shared Luis CoroneliD· 2 shared Martin FischeriD· 2 shared Steve HoffmanniD· 2 shared Anja RaamsiD· 1 shared Arjan F. TheiliD· 1 shared Céline Van Wassenhove· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Katjana SchwabORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 11, 2026

Helicase-deficient TFIIH causes severe disease features via persistent DNA excision without damage removal

David Häckes, Arjan F. Theil, Geun Hoe Kim…·Hannes Lans

The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.

DOI 10.64898/2026.09.05.749590

C. elegansDNA methylation

GenomicsCell Death DiscoveryPeer-reviewedMar 2, 2023

Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

Katjana Schwab, Luis Coronel, Konstantin Riege…·Martin Fischer

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

12 citations

humanbulk RNA-seq

GenomicsNucleic Acids ResearchPeer-reviewedJun 22, 2021

Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress

Luis Coronel, Konstantin Riege, Katjana Schwab…·Martin Fischer

This study identifies RFX7 as a p53-regulated tumor suppressor that activates key genes involved in cell differentiation and apoptosis in response to stress.

39 citations

humanbulk RNA-seq