Martin Fischer

UV laser crosslinking uncovers novel DNA-binding pattern of CTCF

This study uses UV ChIP-seq to identify novel CTCF-DNA interactions, revealing previously undetected binding sites and noncanonical motifs.

Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network

The paper identifies ZMAT3 and CDKN1A as key hubs in the p53 tumor suppression network through integrative multiomic analyses in a mouse model.

The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity

The paper presents a chromosome-level genome assembly of the Greenland shark and identifies genomic features associated with its extreme longevity.

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation

TargetGeneReg 2.0 expands its database to include non-coding genes and new transcription factors, enabling analysis of gene regulation by p53, ΔNp63, and cell cycle signaling.

Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress

This study identifies RFX7 as a p53-regulated tumor suppressor that activates key genes involved in cell differentiation and apoptosis in response to stress.

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

The paper identifies p63 binding sites and predicts its gene regulatory network using ChIP-seq data and motif analysis, highlighting potential therapeutic targets in SCC.