Author

Arjan F. Theil

Erasmus MCORCID 0000-0001-5779-1681Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hannes LansiD· 2 shared Karen L. ThijsseniD· 2 shared Wim VermeuleniD· 2 shared Adriaan B. HoutsmulleriD· 1 shared Alba Muniesa-VargasiD· 1 shared Anja RaamsiD· 1 shared Bart GevertsiD· 1 shared Carlota Davó-MartíneziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenetics

Hannes LansORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 11, 2026

Helicase-deficient TFIIH causes severe disease features via persistent DNA excision without damage removal

David Häckes, Arjan F. Theil, Geun Hoe Kim…·Hannes Lans

The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.

DOI 10.64898/2026.09.05.749590

C. elegansDNA methylation

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GeneticsbioRxivPreprintDec 6, 2024

Regulation of XPG-DNA damage binding dynamics by pre- and post-incision nucleotide excision repair factors and EXO1

Alba Muniesa-Vargas, Cristina Ribeiro-Silva, Bart Geverts…·Hannes Lans

This study investigates how XPG function is regulated during nucleotide excision repair through dynamic interactions with TFIIH, XPA, and EXO1, revealing mechanisms of XPG recruitment and dissociation from DNA damage.

DOI 10.1101/2024.12.06.627128

experimental assay

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