Konstantin Riege

This study identifies nonlinear gene-expression trajectories in the aging male mouse colon, revealing midlife transitions and a transcriptomic clock based on three genes.

The paper improves epigenetic age estimation by developing a TFMethyl Clock model that incorporates transcription factor binding sites, revealing DNA methylation changes linked to aging.

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

The paper integrates multi-omics data from mice to identify molecular features linked to aging-related cognitive decline, highlighting systemic inflammation and microbiome-driven gut-brain axis dysfunction.

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.

This study identifies Transthyretin as a sex-specific target of vitamin B12 that influences stress resilience through DNA methylation changes in the prefrontal cortex.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

This study identifies Npbwr1 as a key regulator of depressive-like symptoms and shows that its antagonist CYM50769 rapidly alleviates these symptoms in mice.

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

TargetGeneReg 2.0 expands its database to include non-coding genes and new transcription factors, enabling analysis of gene regulation by p53, ΔNp63, and cell cycle signaling.

This study identifies RFX7 as a p53-regulated tumor suppressor that activates key genes involved in cell differentiation and apoptosis in response to stress.

The paper identifies p63 binding sites and predicts its gene regulatory network using ChIP-seq data and motif analysis, highlighting potential therapeutic targets in SCC.

The paper introduces shournal, a tool that automatically records Linux shell activity to improve reproducibility of computational workflows.