Author

Mahdi Ghorbani

National Institutes of HealthORCID 0000-0002-2184-4494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Jeffery B. KlaudaiD· 2 shared Bernard R. BrooksiD· 1 shared Kyle C. KihniD· 1 shared Purushottam Babu TiwariiD· 1 shared Samarjeet PrasadiD· 1 shared Tinatin I. BrelidzeiD· 1 shared Xi Chen· 1 shared Ze-Jun Wang· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

Jeffery B. KlaudaORCID

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2 papers

Recent·Most cited

Chlorpromazine inhibits EAG1 channels by altering the coupling between the PAS, CNBH and pore domains

Kyle C. Kihn, Ze-Jun Wang, Xi Chen, Mahdi Ghorbani, Purushottam Babu Tiwari, Jeffery B. Klauda, Tinatin I. Brelidze

This study shows chlorpromazine inhibits EAG1 channels by disrupting PAS-CNBH domain coupling, without affecting VSD movement.

Biophysical Journal · Mar 6, 2026Peer-reviewedBiophysics

Deep attention based variational autoencoder for antimicrobial peptide discovery

Mahdi Ghorbani, Samarjeet Prasad, Bernard R. Brooks, Jeffery B. Klauda

This study uses a variational autoencoder with attention mechanisms to generate novel antimicrobial peptides with physicochemical properties similar to real ones.

bioRxiv · Jul 8, 2022 · PreprintBioinformatics