Author

Purushottam Babu Tiwari

Georgetown UniversityORCID 0000-0002-3140-0723Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Aaron Z. WelchiD· 1 shared Ahmed SeddekiD· 1 shared Andrew Hoy· 1 shared Anqi Feng· 1 shared Arun KrishnarajiD· 1 shared Aykut ÜreniD· 1 shared Christian Madeira· 1 shared Christopher Mederos· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Aaron Z. WelchORCID

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2 papers

Recent·Most cited

Transcriptome-wide mapping reveals a non-canonical RNA-dependent mechanism of platinum cancer drugs

Arun Krishnaraj, Xinrui Wei, Richi Thakral, Weiyi Guo, Siva Bala Subramaniyan, Xiaopei Zhang, Katelyn R. Alley, Anqi Feng, Andrew Hoy, Douglas Kung, Purushottam Babu Tiwari, Aykut Üren, Rodrigo A. Maillard, Victoria J. DeRose, Sreejith J. Nair

The paper identifies cisplatin as an RNA binder and shows its cytotoxicity is partially mediated through RNA binding, revealing a noncanonical mechanism of action.

bioRxiv · Sep 16, 2026 · PreprintMolecular Biology

A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I

Ahmed Seddek, Christian Madeira, Thirunavukkarasu Annamalai, Christopher Mederos, Purushottam Babu Tiwari, Aaron Z. Welch, Yuk‐Ching Tse‐Dinh

This paper develops a yeast-based screening system to identify human TOP1 poison inhibitors and catalytic inhibitors, distinguishing their mechanisms and assessing cytotoxicity.

bioRxiv · Nov 16, 2021 · PreprintMolecular Biology