Author

James C. Iatridis

Icahn School of Medicine at Mount SinaiORCID 0000-0002-2186-0590Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew C. HechtiD· 1 shared Brandon Douglas LawrenceiD· 1 shared Brian O. DiekmaniD· 1 shared C.-J. LiuiD· 1 shared Christian J. LewisiD· 1 shared Damien M. LaudieriD· 1 shared Elena GrossiiD· 1 shared Hunter LevisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Andrew C. HechtORCID

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2 papers

Recent·Most cited

ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms

Christian J. Lewis, Hunter Levis, Jonah Holbrook, Jacob Tyler Polaski, Timothy D. Jacobsen, Josh Mizels, Molly Czachor, Sarah E. Gullbrand, Brian O. Diekman, James C. Iatridis, Jason Gertz, Brandon Douglas Lawrence, Robby D. Bowles

This study identifies ZNF865 as a regulator of cell senescence and DNA damage in intervertebral discs, showing its role in back pain and potential as a therapeutic target.

Aging Cell · Oct 1, 2026Peer-reviewedBioengineering

TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair in back pain conditions

Jennifer Gansau, Elena Grossi, Levon Rodriguez, Minghui Wang, Damien M. Laudier, Saad B. Chaudhary, Andrew C. Hecht, Wenyu Fu, Robert Sebra, C.-J. Liu, James C. Iatridis

This study identifies TNFR1-mediated senescence and limited TNFR2 signaling as barriers to intervertebral disc cell repair in back pain, suggesting immunomodulation as a therapeutic strategy.

Osteoarthritis and Cartilage · Mar 24, 2025Peer-reviewedBioengineering