TERRA is a foundation model for spatial transcriptomics that predicts tissue behavior under perturbation and identifies multi-scale biological insights across tissues.

bioRxiv · Aug 4, 2026 · PreprintGenomics

A network medicine framework for multi-modal data integration in therapeutic target discovery

Greta Baltušytė, Isaac Toleman, James O. Jones, Sarah Joanne Welsh, Grant Duncan Stewart, Thomas J. Mitchell, Kourosh Saeb‐Parsy, Namshik Han

This paper presents a network medicine framework integrating multi-modal data to identify therapeutic targets in clear cell renal cell carcinoma, recovering established targets and predicting five candidates, with ENO2 inhibition showing the strongest anti-tumour effect.

Communications Chemistry · May 6, 2026Peer-reviewedBioinformatics

Angiogenic and Immune Predictors of Neoadjuvant Axitinib Response in Renal Cell Carcinoma with Venous Tumour Thrombus

Rebecca Wray, Hania Paverd, Ines Prata Machado, Johanna Barbieri, Farhana Easita, Abigail R. Edwards, Ferdia Aidan Gallagher, Iosif Alexandru Mendichovszky, Thomas J. Mitchell, Maike de la Roche, Jacqueline D. Shields, Stephan Ursprung, Lauren Wallis, Anne Yvonne Warren, Sarah Joanne Welsh, , Robert J. Jones

The paper assesses neoadjuvant axitinib response in RCC with VTT using multiparametric analysis and identifies angiogenic and immune predictors of treatment response.

Nature Communications · Apr 28, 2025Peer-reviewedCancer Biology