Luisa Cutillo

GRASPS identifies more differentially expressed transcripts with higher fold changes and significance in TDP-43 ALS models, revealing previously missed disease pathways.

This study shows that inhibiting SRSF1-dependent nuclear export of C9ORF72-repeat transcripts in ALS models protects neurons and identifies key RNA changes involved in disease.

OscoNet improves upon Oscope by providing a statistical criterion for selecting oscillatory genes and a more accurate pseudo-time estimation method.