Mario Rosario Guarracino

The paper introduces HELP, a framework for labelling and predicting human essential genes, showing it outperforms existing methods in balancing false and true positive rates.

GRASPS identifies more differentially expressed transcripts with higher fold changes and significance in TDP-43 ALS models, revealing previously missed disease pathways.

The paper provides a dataset and R package to benchmark CRISPR-Cas9 screening pipelines using HT-29 cells and a commercial guide RNA library.

This study identifies TBXT's role in early posterior regionalisation of human neural crest cells through chromatin remodelling and WNT signalling.

This study shows that inhibiting SRSF1-dependent nuclear export of C9ORF72-repeat transcripts in ALS models protects neurons and identifies key RNA changes involved in disease.

This study identifies signalling pathways that guide the generation of posterior ventral spinal cord motor neurons from human pluripotent stem cells.

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.