The paper introduces HELP, a framework for labelling and predicting human essential genes, showing it outperforms existing methods in balancing false and true positive rates.

PLoS Computational Biology · Sep 27, 2024Peer-reviewedBioinformatics

GRASPS: a simple-to-operate translatome technology reveals omics-hidden disease-associated pathways in TDP-43-related amyotrophic lateral sclerosis

Ya-Hui Lin, Jennifer E. Dodd, Luisa Cutillo, Lydia M. Castelli, Simeon R. Mihaylov, Karl Norris, Adrian Higginbottom, Matthew J. Walsh, Johnathan Cooper‐Knock, J. Robin Highley, Ilaria Granata, Caroline A. Evans, Mario Rosario Guarracino, Susan G. Campbell, Mark J. Dickman, , Guillaume M. Hautbergue

GRASPS identifies more differentially expressed transcripts with higher fold changes and significance in TDP-43 ALS models, revealing previously missed disease pathways.

bioRxiv · Mar 4, 2024 · PreprintMolecular Biology

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

Antigoni Gogolou, Céline Souilhol, Ilaria Granata, Filip J. Wymeersch, Ichcha Manipur, Matthew Wind, Thomas J.R. Frith, Maria Guarini, Alessandro Bertero, Christoph Bock, Florian Halbritter, Minoru Takasato, Mario Rosario Guarracino, Anestis Tsakiridis

This study identifies TBXT's role in early posterior regionalisation of human neural crest cells through chromatin remodelling and WNT signalling.

eLife · Sep 26, 2022Peer-reviewedDevelopmental Biology

Safety and efficacy of C9ORF72-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosis

Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Álvaro Sánchez-Martínez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul Roy Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario Rosario Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, , Guillaume M. Hautbergue

This study shows that inhibiting SRSF1-dependent nuclear export of C9ORF72-repeat transcripts in ALS models protects neurons and identifies key RNA changes involved in disease.

Molecular Neurodegeneration · Aug 10, 2021Peer-reviewedSystems Biology

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

Matthew Wind, Antigoni Gogolou, Ichcha Manipur, Ilaria Granata, Larissa Butler, Peter W. Andrews, Ivana Barbaric, Ke Ning, Mario Rosario Guarracino, Marysia Placzek, Anestis Tsakiridis

This study identifies signalling pathways that guide the generation of posterior ventral spinal cord motor neurons from human pluripotent stem cells.

Development · Mar 3, 2021Peer-reviewedDevelopmental Biology

Human axial progenitors generate trunk neural crest cells

Thomas J.R. Frith, Ilaria Granata, Matthew Wind, Erin Stout, Oliver Thompson, Katrin Neumann, Dylan Stavish, Paul Roy Heath, Daniel Ortmann, James O.S. Hackland, Konstantinos Anastassiadis, Mina Gouti, James Briscoe, Valerie A. Wilson, Stuart L. Johnson, , Anestis Tsakiridis

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.

eLife · Aug 10, 2018Peer-reviewedDevelopmental Biology