William Christopher Risher

Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus

This study shows that adolescent alcohol exposure disrupts astrocyte-synaptic coupling in male rats, leading to persistent behavioral impairments that can be partially reversed by astrocyte activation.

SynBot: An open-source image analysis software for automated quantification of synapses

SynBot is an open-source software for automated synapse quantification from light microscopy images, improving speed, reproducibility, and ease of use.

Abnormal morphology and synaptogenic signaling in astrocytes following prenatal opioid exposure

This study examines how prenatal opioid exposure affects astrocyte morphology and synaptogenic signaling in cortical cultures, revealing altered synaptic development and stress responses in neurons.

Alterations in excitatory and inhibitory synaptic development within the mesolimbic dopamine pathway in a mouse model of prenatal drug exposure

This study examines the effects of prenatal drug exposure on synaptogenesis in the mesolimbic dopamine pathway in mice, finding increased excitatory and decreased inhibitory synapses in specific brain regions.

Astrocyte-derived thrombospondin induces cortical synaptogenesis in a sex-specific manner.

This study shows that astrocyte-derived thrombospondin induces synaptogenesis in male but not female cortical neurons, mediated by estrogen signaling.