Justin T Savage

This study shows that δ-catenin regulates astrocyte transcriptional maturation and circuit stabilization via Zbtb20, with loss of δ-catenin disrupting layer-specific astrocyte identities and prolonging ocular dominance plasticity.

SynBot is an open-source software for automated synapse quantification from light microscopy images, improving speed, reproducibility, and ease of use.

This study identifies Neurocan as an astrocyte-secreted protein that promotes inhibitory synapse formation and function through its C-terminal fragment.

The paper introduces GEARBOCS, an AAV-based CRISPR/Cas9 tool for in vivo astrocyte gene editing, demonstrating its utility for knockout, tagging, and reporter knock-in strategies in mice.