James C. Williamson

This study identifies ZFAND5/6 as ubiquitin-independent proteasome activators that regulate NF-κB signaling by degrading UBCH5c.

The paper identifies CBF-beta as a negative regulator of STING through synthetic lethality screens in VHL-null ccRCC cells, showing its role in type I interferon signaling and tumor growth.

This study generates HLA-edited cholangiocyte organoids with reduced immunogenicity and reports their mutation profiles and immune response in vitro and in vivo.

This study develops i3Neuron models of Tay-Sachs and Sandhoff diseases, revealing plasma membrane remodeling and synaptic dysfunction due to GM2 ganglioside accumulation.

The paper shows that altered sulfatide-binding by NF155 links glycosphingolipid imbalances to demyelination by affecting membrane protein abundance and axon-myelin contacts.

This study examines the effects of prenatal drug exposure on synaptogenesis in the mesolimbic dopamine pathway in mice, finding increased excitatory and decreased inhibitory synapses in specific brain regions.

This study shows that astrocyte-derived thrombospondin induces synaptogenesis in male but not female cortical neurons, mediated by estrogen signaling.

The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.

This study shows neural stem cells transfer functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells, improving disease outcomes in multiple sclerosis.