NeuroscienceBiological PsychiatryPeer-reviewed
TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons
Brittany A. Davis, Huei-Ying Chen, Zengyou Ye…·Brady J. Maher
This study shows TCF4 mutations impair synaptic function in patient-derived cortical neurons by disrupting RIMBP2 expression, leading to deficits in synaptic transmission and network excitability.