Author

Kate C. Mellor

Wellcome Sanger InstituteORCID 0000-0002-2247-4675Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Lesley McGeeiD· 3 shared Stephanie W. LoiD· 3 shared Stephen D. BentleyiD· 3 shared Alannah C. KingiD· 2 shared Gemma G. R. MurrayiD· 2 shared John A. LeesiD· 2 shared Akuzike Kalizang’omaiD· 1 shared Andrew John PollardiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Lesley McGeeORCID

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3 papers

Recent·Most cited

Global population structure and phase variation of serotype 12F Streptococcus pneumoniae following the introduction of pneumococcal conjugate vaccine

Thi N M Huynh, Alannah C. King, Jason Chen Qixiang, Kathryn M Mulvihill, Hayley Demetriou, Kate C. Mellor, Rebecca A. Gladstone, Gemma G. R. Murray, Oliver Lorenz, Harry C. H. Hung, Teodora Mateeva, Sonu Shrestha, Sarah A. Kelly, Andrew John Pollard, Shrijana Shrestha, , Stephanie W. Lo

This study characterizes the global population structure and genetic diversity of serotype 12F Streptococcus pneumoniae, identifying strand-slippage mutations as a mechanism for capsule variation and vaccine evasion.

bioRxiv · Apr 7, 2026 · PreprintGenomics

Comparison of gene-by-gene and genome-wide short nucleotide sequence based approaches to define the global population structure of Streptococcus pneumoniae

Alannah C. King, Narender Kumar, Kate C. Mellor, Paulina A. Hawkins, Lesley McGee, Nicholas J. Croucher, Stephen D. Bentley, John A. Lees, Stephanie W. Lo

This paper compares four clustering methods for S. pneumoniae genomes to assess their accuracy in reflecting population structure and highlights the need for standardized nomenclature.

Microbial Genomics · Aug 28, 2024Peer-reviewedGenomics

Evidence of virulence and antimicrobial resistance in Streptococcus pneumoniae serotype 16F lineages

Jolynne Mokaya, Kate C. Mellor, Gemma G. R. Murray, Akuzike Kalizang’oma, Cebile Natasha Lekhuleni, Heather Joy Zar, Mark Patrick Nicol, Lesley McGee, Stephen D. Bentley, Stephanie W. Lo, Felix Sizwe Dube

This study characterizes serotype 16F Streptococcus pneumoniae lineages and antimicrobial resistance in South African infants and globally, finding associations with disease and resistance.

bioRxiv · Aug 25, 2023 · PreprintGenomics