Author

Hayley Demetriou

UCL Biomedical Research Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

David GoldblattiD· 2 shared Akuzike Kalizang’omaiD· 1 shared Alannah C. KingiD· 1 shared Amal Alsari· 1 shared Andrew John PollardiD· 1 shared Catherine SatzkeiD· 1 shared Chris Lok To Sham· 1 shared Chrispin ChaguzaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

David GoldblattORCID

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2 papers

Recent·Most cited

Global population structure and phase variation of serotype 12F Streptococcus pneumoniae following the introduction of pneumococcal conjugate vaccine

Thi N M Huynh, Alannah C. King, Jason Chen Qixiang, Kathryn M Mulvihill, Hayley Demetriou, Kate C. Mellor, Rebecca A. Gladstone, Gemma G. R. Murray, Oliver Lorenz, Harry C. H. Hung, Teodora Mateeva, Sonu Shrestha, Sarah A. Kelly, Andrew John Pollard, Shrijana Shrestha, , Stephanie W. Lo

This study characterizes the global population structure and genetic diversity of serotype 12F Streptococcus pneumoniae, identifying strand-slippage mutations as a mechanism for capsule variation and vaccine evasion.

bioRxiv · Apr 7, 2026 · PreprintGenomics

Streptococcus pneumoniae accessory capsular genes modulate fitness, pathogenicity and immune evasion

Jia Mun Chan, Helen R. Flynn, Suji Kim, Hayley Demetriou, Elisa Ramos‐Sevillano, Amal Alsari, Lucy Roalfe, Giuseppe Ercoli, Akuzike Kalizang’oma, Comfort Brown, Chrispin Chaguza, Neil French, Jeremy Brown, David Goldblatt, Luiz Pedro S. de Carvalho, Robert S. Heyderman

The paper shows that accessory capsular genes in Streptococcus pneumoniae enhance fitness, pathogenicity, and immune evasion without capsule switching.

bioRxiv · Sep 11, 2025 · PreprintMicrobiology