Lesley McGee

This study examines capsule switching in Streptococcus pneumoniae using whole-genome sequences, finding that switching is limited to specific capsule-type pairs and influenced by genetic and ecological factors.

This study characterizes the global population structure and genetic diversity of serotype 12F Streptococcus pneumoniae, identifying strand-slippage mutations as a mechanism for capsule variation and vaccine evasion.

This paper introduces SeroBA(v2.0), a tool for pneumococcal serotyping, and SeroBAnk, a resource for capsular diversity, which accurately identifies 102 serotypes and supports community contributions for updates.

The paper introduces GPS Pipeline, a scalable and portable genomic analysis tool for Streptococcus pneumoniae, enabling public health outputs with minimal expertise.

This paper compares four clustering methods for S. pneumoniae genomes to assess their accuracy in reflecting population structure and highlights the need for standardized nomenclature.

This study characterizes serotype 16F Streptococcus pneumoniae lineages and antimicrobial resistance in South African infants and globally, finding associations with disease and resistance.

The paper reconstructs the evolutionary histories of antibiotic-resistant pneumococcal lineages PMEN3 and PMEN9, showing how interspecies recombination contributes to antibiotic resistance and serotype switching.

This paper analyzes pneumococcal carriage genomic data before and after PCV13 introduction, showing reduced vaccine-type strains and limited serotype replacement.