Victor Bustos

This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.

The paper introduces two CRISPR-based methods, CRISPR-CLONInG and CRISPR-CLIP, for constructing donor DNA templates for genome editing, demonstrating their efficiency and versatility in generating dsDNA and lssDNA donors.

The paper shows C99 accumulates in vulnerable neurons in Alzheimer’s disease and correlates with cognitive impairment, while beta-amyloid levels increase in both vulnerable and resistant areas.