Linda Partridge

The paper analyzes how body weight affects the effectiveness of lifespan-extending interventions in mice, finding that heavier mice show greater lifespan benefits.

The paper identifies a Wolbachia protein that enhances Drosophila resistance to virus infection via the IMD pathway.

The paper performs a transcriptome-wide association study on human lifespan and validates findings in Drosophila, identifying COASY as a gene involved in ageing across species.

This paper uses demographic data to show how human ageing has changed due to demographic transition, with reduced selection pressure on late-life traits.

This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.

This study shows that combining trametinib and rapamycin extends mouse lifespan more than either drug alone and improves health markers in older age.

The paper identifies reduced PUFA levels in FTD/ALS models and shows neuronal PUFA supplementation improves survival and reduces neuronal death.

This study examines how a lifestyle intervention affects the blood transcriptomic and metabolomic responses to a nutrient challenge in elderly individuals.

This study shows that enhancing autophagy through redox regulation extends lifespan in Drosophila by highlighting the role of a specific cysteine residue in Atg4a.

This study shows that inhibiting S6K in Drosophila and mice reduces age-related inflammation and extends lifespan through the endolysosomal system and immune pathways.

This study shows that Gba1 deletion in flies causes immune hyperactivation and microbial dysbiosis, which can be mitigated by microbiome modulation or autophagy stimulation.

This study shows that retaining proteins in the ER can rescue Aβ toxicity in Drosophila and mouse models, suggesting a potential therapeutic strategy for Alzheimer's disease.

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.

The paper identifies two rare variants in the MAPK/ERK pathway from long-lived families and shows they affect signaling and metabolism differently in mouse embryonic stem cells.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

This study identifies male-specific brain aging improvements from reduced neuronal insulin signaling in mice.

The paper identifies the one carbon folate cycle as a shared metabolic mechanism regulating longevity across species.

The paper identifies aging mechanisms that predict age-related disease multimorbidities in humans using literature analysis and clinical data integration.

This study identifies genetic associations between age-related diseases, finding four clusters with shared age-of-onset profiles and aging-related genes, and suggests drug repurposing for multiple age-dependent diseases.

This study compares transcriptomic changes in long- and short-lived mouse models of ageing, identifying mitochondrial metabolism as a key factor and showing that progeroid mice exhibit gene expression patterns similar to normal ageing.

The paper develops a computational model of the Drosophila melanogaster Giant Fiber System to study escape response latency and identifies anatomical factors as more influential than membrane conductance.

The paper identifies anti-ageing drug candidates by analyzing drug-protein interactions and validates one candidate in C. elegans.

The paper identifies Plum as a regulator of neuromuscular function and muscle size in Drosophila by modulating Myoglianin activity.

This study uses gene expression data to identify drugs that may combat ageing by comparing age-related gene changes with drug-induced profiles.