DNA-binding-independent mechanisms of metabolic regulation by the Drosophila FOXO transcription factor
Victor Bustos, Lauren Mcdonagh, Bruna Di Giacomo, Ralf Leslie Meilenbrock, Jacqueline Eßer, Sebastian Grönke, Cathy Slack, Linda Partridge
This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.
bioRxiv · Aug 20, 2025 · PreprintGenetics