Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging
Teresa Delgado‐Goñi, Natalie Connor‐Robson, Milena Cioroch, Stephen J. Paisey, Christopher Marshall, Emma L. Lane, David Hauton, James McCullagh, Peter J. Magill, Stephanie Jane Cragg, Clare E. Mackay, Richard Wade‐Martins, Johannes Christian Klein
The paper uses PET imaging to show increased dopamine D2 receptor binding in LRRK2-R1441C rats, suggesting receptor upregulation as a compensatory response to dopamine deficits.
bioRxiv · Aug 9, 2023 · PreprintNeuroscience