Stephanie Jane Cragg

Calcium-independent biosensors for multiplexed in vivo imaging of extracellular lactate dynamics

The paper develops Ca2+-independent lactate biosensors for multiplexed in vivo imaging of extracellular lactate dynamics alongside neuronal activity.

Selective GRAB sensors reveal distinct endocannabinoid dynamics in vivo

The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.

5-HT4 receptor ligand RS67333 modulates striatal acetylcholine and dopamine release via inhibition of acetylcholinesterase

This study shows RS67333 modulates striatal dopamine and acetylcholine release by inhibiting acetylcholinesterase, not through 5-HT4R activation, and highlights the potential of AChE inhibitors for treating ACh/DA disorders.

A human GBA-L444P transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson's disease

This paper creates a humanised GBA-L444P mouse model to study GBA1 mutations in Parkinson's, finding gain-of-function effects on dopamine release and loss-of-function effects on alpha-synuclein pathology.

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

This study shows that the superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning by developing neuronal responses to the CS and requiring convergence of visual, dopamine, and serotonin inputs.

Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading

The paper investigates dopamine release defects in Parkinson's patient-derived neurons and identifies reduced VMAT2 function as the cause.

An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement

The paper identifies an anatomical hotspot in the anterior dorsolateral striatum where dopamine and acetylcholine interactions are spatially organized and influence behaviorally relevant dynamics during reward and movement.

Gabapentinoids promote striatal dopamine release and rescue multiple deficits of a mouse model of early Parkinson's

This study shows gabapentinoids enhance dopamine release in a Parkinson's mouse model and improve movement deficits by modulating calcium and GABAergic signaling.

An axonal brake on striatal dopamine output by cholinergic interneurons

This study shows that cholinergic interneurons in the striatum use nicotinic receptors to limit dopamine release by depressing axonal depolarization and calcium summation.

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes

The paper reveals that striatal astrocytes rapidly modulate cholinergic interneurons and dopamine release through subsecond calcium dynamics in mice and humans.

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging

The paper uses PET imaging to show increased dopamine D2 receptor binding in LRRK2-R1441C rats, suggesting receptor upregulation as a compensatory response to dopamine deficits.

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

This study investigates how mTORC1 and mTORC2 differentially regulate dopamine neuron morphology and function in mice, revealing distinct effects on structure, excitability, and dopamine output.

Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol

This study investigates how adenosine A1 receptors inhibit dopamine release in the nucleus accumbens, showing that astrocytic ENT1 regulates this inhibition and that ethanol disrupts it.

Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

The paper investigates the role of astrocytic GABA transporters in regulating dopamine release in the striatum and shows their downregulation in early parkinsonism.

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

The paper investigates short-term plasticity in dopamine release in the striatum, finding that it is primarily governed by axonal properties and the dopamine transporter rather than initial release levels.