Peter J. Magill

The paper maps pallidostriatal connectivity in mice, showing distinct innervation patterns of striatal neuron subpopulations by different pallidal neuron types.

This paper introduces ASA-PD, an imaging method to detect and map α-synuclein oligomers in Parkinson's disease brain tissue, revealing a specific subpopulation of nanoscale oligomers as an early hallmark of the disease.

The paper identifies Anxa1+ dopamine neurons as vulnerable in prodromal Parkinson's disease, linking their dysfunction to bradykinesia and procedural motor learning impairments.

The paper reveals that striatal astrocytes rapidly modulate cholinergic interneurons and dopamine release through subsecond calcium dynamics in mice and humans.

The paper identifies multiple spatially discrete beta ensembles in parkinsonian cortico-basal ganglia networks, showing they form functionally connected clusters of neurons.

The paper uses PET imaging to show increased dopamine D2 receptor binding in LRRK2-R1441C rats, suggesting receptor upregulation as a compensatory response to dopamine deficits.

This study identifies a selective subthalamostriatal projection to parvalbumin-expressing interneurons in the striatum, showing higher connectivity and excitatory responses compared to other cell types.

This study investigates the aperiodic exponent of subthalamic field potentials in Parkinsonism across species, finding it reflects excitation/inhibition balance and could be a biomarker for adaptive deep brain stimulation.

The paper investigates how reward information and task variables are encoded in midbrain dopamine neurons projecting to different striatal regions, showing heterogeneous and distributed coding.

This paper demonstrates how connectivity in the cortico-basal-ganglia circuit influences beta oscillations and shows that phase-locked stimulation can modulate these oscillations based on network state.

This study investigates thalamic dysrhythmia in Parkinsonism by comparing activity in dopamine-intact and 6-OHDA-lesioned rats, finding zone-selective abnormalities in the basal ganglia-recipient zone.

The paper investigates the role of astrocytic GABA transporters in regulating dopamine release in the striatum and shows their downregulation in early parkinsonism.

This study shows that loss of Tsc1 in midbrain dopamine neurons leads to structural and functional defects, causing cognitive flexibility deficits that can be mitigated by reducing Raptor.

This study examines beta burst dynamics in the cortico-basal ganglia network of PD patients and rats, showing phase relationships and rhythmic activity patterns that correlate with motor impairment.

This study investigates the neural mechanisms underlying transitions in cortical beta power in Parkinsonian rats using dynamic causal modeling and identifies key thalamocortical coupling patterns.

The paper investigates changes in directed connectivity within cortico-basal ganglia networks in Parkinsonian rats following dopamine depletion, finding dopamine-dependent beta and gamma rhythms and altered connections.