Natalie Connor‐Robson

This paper develops a highly efficient lentiviral transduction method for human iPSC-derived microglia and macrophages using a modified promoter and plasmid design.

This paper creates a humanised GBA-L444P mouse model to study GBA1 mutations in Parkinson's, finding gain-of-function effects on dopamine release and loss-of-function effects on alpha-synuclein pathology.

This study uses human iPSC-derived microglia with high polygenic AD risk to identify functional impairments in immune response, mitochondrial function, and amyloid-beta uptake.

The paper profiles spatial transcriptomic and translatomic data of dopaminergic neurons in young and old mice, identifying markers of aging and disease-related pathways, and highlights CASR as a novel regulator of dopaminergic calcium handling.

This study shows that reducing tau in human neurons decreases A beta toxicity, supporting the role of tau in Alzheimer's disease mechanisms.

The paper uses PET imaging to show increased dopamine D2 receptor binding in LRRK2-R1441C rats, suggesting receptor upregulation as a compensatory response to dopamine deficits.

The paper investigates the role of astrocytic GABA transporters in regulating dopamine release in the striatum and shows their downregulation in early parkinsonism.