Author

Herman O. Sintim

Purdue University West LafayetteORCID 0000-0002-2280-9359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Colby Hladun· 1 shared Costel C. DarieiD· 1 shared Danielle WhithamiD· 1 shared Danna WangiD· 1 shared Jared Morse· 1 shared Ka‐Ho LeungiD· 1 shared Meiping YeiD· 1 shared Modi Wang· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

Colby Hladun

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2 papers

Recent·Most cited

Borrelia burgdorferi Secretes c-di-AMP as an Extracellular Pathogen-Associated Molecular Pattern to Elicit Type I Interferon Responses in Mammalian Hosts

Raj Priya, Meiping Ye, Sajith Raghunandanan, Qiang Liu, Wei Li, Qigui Yu, Yongliang Lou, Herman O. Sintim, Xiuli Yang

This study identifies c-di-AMP as a key extracellular PAMP secreted by Borrelia burgdorferi that triggers type I interferon responses in mammalian hosts via STING signaling.

The Journal of Immunology · Jul 3, 2025Peer-reviewedImmunology

Chloride Homeostasis Regulates cGAS-STING Signaling

Jared Morse, Danna Wang, Serena Mei, Danielle Whitham, Colby Hladun, Costel C. Darie, Herman O. Sintim, Modi Wang, Ka‐Ho Leung

This study shows chloride homeostasis regulates cGAS-STING signaling by affecting 23-cGAMP production, STING polymerization, and cytokine production in immune cells.

bioRxiv · Apr 8, 2024 · PreprintCell Biology