Qigui Yu

Borrelia burgdorferi Secretes c-di-AMP as an Extracellular Pathogen-Associated Molecular Pattern to Elicit Type I Interferon Responses in Mammalian Hosts

This study identifies c-di-AMP as a key extracellular PAMP secreted by Borrelia burgdorferi that triggers type I interferon responses in mammalian hosts via STING signaling.

CD1d-dependent neuroinflammation impairs tissue repair and functional recovery following a spinal cord injury

This study shows CD1d promotes proinflammatory responses after spinal cord injury, impairing tissue repair and functional recovery, and identifies CD1d as a potential therapeutic target.

PD-L1-expressing astrocytes act as a gate-keeper for neuroinflammation in the central nervous system of mice with traumatic brain injury

This study identifies PD-L1-expressing astrocytes as regulators of neuroinflammation in TBI, showing their role in limiting excessive immune responses and improving outcomes.