Raj Priya

Type I interferon signaling promotes early innate control of Borrelia burgdorferi infection

This study shows that type I interferon signaling is critical for early control of Borrelia burgdorferi infection by enhancing macrophage function and immune cell recruitment, but contributes to inflammation later in infection.

Borrelia burgdorferi Secretes c-di-AMP as an Extracellular Pathogen-Associated Molecular Pattern to Elicit Type I Interferon Responses in Mammalian Hosts

This study identifies c-di-AMP as a key extracellular PAMP secreted by Borrelia burgdorferi that triggers type I interferon responses in mammalian hosts via STING signaling.

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen

This study identifies a positive feedback loop between RpoS and BosR in Borrelia burgdorferi, showing RpoS regulates BosR protein levels through post-transcriptional mechanisms.

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi

This study identifies MCP5 as essential for Borrelia burgdorferi's immune evasion and transmission, regulated by two signaling pathways.

CD1d-dependent neuroinflammation impairs tissue repair and functional recovery following a spinal cord injury

This study shows CD1d promotes proinflammatory responses after spinal cord injury, impairing tissue repair and functional recovery, and identifies CD1d as a potential therapeutic target.