This study examines the association between maternal and fetal HLA heterozygosity and preeclampsia risk in a large multi-ancestry cohort, finding protective and risk associations for specific HLA loci.

HLA · Sep 1, 2026Peer-reviewedGenetic & Genomic Medicine

Multi-omic integration reveals dynamic changes in human placental metabolism across gestation

Mariana Parenti, Sam Rosen, Maya Pettes, Danijel Djukovic, Daniel Raftery, Ian A. Glass, Kathryn J. Gray, Alison G. Paquette, Stephen A. McCartney

The paper integrates metabolomic and transcriptomic data to identify dynamic changes in placental metabolism across trimesters in human pregnancy.

bioRxiv · Oct 22, 2025 · PreprintSystems Biology

Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?

Lydia L. Shook, Evan A. Bordt, Marie-Charlotte Meinsohn, David Pépin, Rose M. De Guzman, Sara M. Brigida, Laura J. Yockey, Kaitlyn E. James, Mackenzie W. Sullivan, Lisa M. Bebell, Drucilla Jane Roberts, Anjali J. Kaimal, Jonathan Z. Li, Danny Joseph Schust, Kathryn J. Gray, Andrea G. Edlow

The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.

bioRxiv · Apr 1, 2021 · PreprintDevelopmental Biology

Risk of preeclampsia in patients with genetic predisposition to common medical conditions: a case-control study

Kathryn J. Gray, Vesela Kovacheva, Hooman Mirzakhani, Andrew Bjonnes, Berta Almoguera, Melissa L. Wilson, Sue A. Ingles, Charles Joseph Lockwood, Hakon H. Hakonarson, Thomas Frederick McElrath, Jeffrey Clark Murray, Errol R. Norwitz, S. Ananth Karumanchi, Brian T. Bateman, Brendan J. Keating, Richa Saxena

This study investigates whether genetic predisposition to medical conditions linked to preeclampsia risk increases preeclampsia risk, finding associations with diastolic blood pressure and BMI.

bioRxiv · Mar 4, 2020 · PreprintGenetics