Cancer BiologyCell Death and DiseasePeer-reviewed
Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.
Aimilia Vareli, Haripriya Vaidehi Narayanan, Heather Clark…·Simon A. Mitchell
This study identifies resistance mechanisms to BH3-mimetics in DLBCL and shows that combining BCL2 inhibition with non-canonical NF-κB inhibition overcomes microenvironment-mediated resistance.
7 citations