This study identifies resistance mechanisms to BH3-mimetics in DLBCL and shows that combining BCL2 inhibition with non-canonical NF-κB inhibition overcomes microenvironment-mediated resistance.

Cell Death and Disease · Aug 16, 2025Peer-reviewedCancer Biology

A novel in-vitro model of the bone marrow microenvironment in AML identifies CD44 and Focal Adhesion Kinase as therapeutic targets to reverse cell adhesion-mediated drug resistance

Eleni E Ladikou, K. Sharp, Fabio A. Simoes, John R Jones, Thomas A. Burley, Lauren Stott, Aimilia Vareli, Emma Kennedy, Sophie Vause, Timothy J. T. Chevassut, Amarpreet Devi, Iona Ashworth, David M. Ross, Tanja Nicole Hartmann, Simon A. Mitchell, , Andrea G. S. Pepper

This study identifies CD44 and FAK as therapeutic targets to reverse adhesion-mediated drug resistance in AML by developing an in-vitro BMME model and testing their synergistic effects.

Cancers · Jan 3, 2025Peer-reviewedCancer Biology

Manipulating the 3D organization of the largest synthetic yeast chromosome

Weimin Zhang, Luciana Lazar‐Stefanita, Hitoyoshi Yamashita, Michael J. Shen, LESLIE ANN MITCHELL, Hikaru Kurasawa, Evgenii Lobzaev, Viola Fanfani, Max A. B. Haase, Xiaoji Sun, Qingwen Jiang, Gregory W. Goldberg, David M. Ichikawa, Stephanie L. Lauer, Laura H. McCulloch, , Jef D. Boeke

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

Molecular Cell · Nov 8, 2023Peer-reviewedSynthetic Biology