Author
Brighton and Sussex Medical SchoolORCID 0000-0003-1091-6349Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Aimilia Vareli, Haripriya Vaidehi Narayanan, Heather Clark…·Simon A. Mitchell
This study identifies resistance mechanisms to BH3-mimetics in DLBCL and shows that combining BCL2 inhibition with non-canonical NF-κB inhibition overcomes microenvironment-mediated resistance.
Eleni E Ladikou, K. Sharp, Fabio A. Simoes…·Andrea G. S. Pepper
This study identifies CD44 and FAK as therapeutic targets to reverse adhesion-mediated drug resistance in AML by developing an in-vitro BMME model and testing their synergistic effects.
Richard Norris, John R Jones, Erika J. Mancini…·Simon A. Mitchell
Ielyaas Cloete, Victoria M. Smith, Ross A. Jackson…·Simon A. Mitchell
This study uses computational systems biology to predict DLBCL cell response to BH3-mimetics by modeling molecular variability and genetic lesions.
Ranmal Aloka Samarasinghe, Osvaldo A. Miranda, Jessie E. Buth…·Bennett G. Novitch
This study identifies neural oscillations and epileptiform changes in human brain organoids derived from MECP2 mutant patients using calcium imaging and extracellular recordings.
Marie Oliver Metzig, Ying Tang, Simon A. Mitchell…·Alexander Hoffmann
The paper identifies an incoherent feedforward loop involving NFκB/RelA and A20 that determines TNF-induced necroptosis decisions based on dynamic signaling.
Kyu‐Hyeon Yeom, Simon A. Mitchell, Anthony J. Linares…·Douglas L. Black
The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.