Jerrold L. Vitek

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus

This paper develops a computational model of the parkinsonian subthalamic nucleus showing how synchronized bursting produces beta-HFO coupling and explains HFO frequency shifts.

Fast Generalized Longitudinal Functional Principal Components Analysis with Applications to Population-Level Neuronal Dynamics

This paper introduces a fast generalized LFPCA method for analyzing longitudinal functional data, showing it is faster and scalable while applied to neuronal firing rate data under DBS.

Spontaneous eye behavior is an objective marker of parkinsonian severity

The paper shows that spontaneous eye behavior in a nonhuman primate PD model correlates with disease severity and beta oscillatory activity, suggesting it as a potential biomarker.

Parkinsonism disrupts the population-level organization of cortical dynamics

This study investigates how parkinsonism alters population-level neural activity in M1 during movement, finding increased dimensionality and reduced orthogonality between preparatory and movement-related subspaces.

Sleep firing rate homeostasis is disrupted in mild parkinsonism

The paper investigates sleep firing rate homeostasis in a nonhuman primate model of Parkinson's disease and finds it is disrupted in parkinsonism.

Transcranial Alternating Current Stimulation can disrupt or reestablish neural entrainment in a primate model of Parkinson's disease

This study investigates how tACS affects neural entrainment in a primate model of Parkinson's disease, finding that it can both disrupt and reestablish beta-band oscillations depending on stimulation parameters.

Parkinsonism disrupts neuronal modulation in the pre-supplementary motor area during movement preparation

This study examines how parkinsonism affects neuronal activity in the pre-SMA during movement preparation in non-human primates, finding disrupted modulation and reduced predictive encoding of reaction time.

Impairment of Neuronal Activity in the Dorsolateral Prefrontal Cortex Occurs Early in Parkinsonism

This study examines how neuronal activity in the dorsolateral prefrontal cortex changes in parkinsonism using nonhuman primates and finds early impairment in task-related firing rates.

Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism

The paper links excessive cortical beta oscillations to slow-wave sleep dysfunction in mild parkinsonism using a nonhuman primate model.

REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?

This study examines the role of the basal ganglia in REM sleep movements in Parkinson's disease, finding distinct oscillatory patterns compared to awake movements.

Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human

This study demonstrates real-time control of pallidal oscillations in Parkinson's disease using evoked interference deep brain stimulation (eiDBS) to suppress or amplify beta band activity.

Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus region

The paper uses ECAP features to classify electrode locations in the STN and surrounding regions to improve DBS therapy for Parkinson's disease.

High-frequency oscillations in the internal globus pallidus: a pathophysiological biomarker in Parkinson's disease?

This study identifies high-frequency oscillations in the internal globus pallidus as a pathophysiological feature of Parkinson's disease using clinical and preclinical data.

Deep-learning based fully automatic segmentation of the globus pallidus interna and externa using ultra-high 7 Tesla MRI

This paper introduces GP-net, a deep-learning model for automatic segmentation of the globus pallidus interna and externa using 7 Tesla MRI, showing improved results over atlas-based methods.

Real-time suppression and amplification of frequency-specific neural activity using stimulation evoked oscillations

This study develops a closed-loop neural control framework to suppress or amplify specific low-frequency oscillations in real-time using electrical stimulation in nonhuman primates.

Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates

This study shows that transcranial alternating current stimulation (TACS) modulates spike timing in awake nonhuman primates in a dose-dependent manner, with higher intensities increasing neuronal entrainment.

Automatic Localization of the Subthalamic Nucleus on Patient-Specific Clinical MRI by Incorporating 7T MRI and Machine Learning: Application in Deep Brain Stimulation

This paper develops an automatic method to localize the subthalamic nucleus on standard clinical MRI using 7T MRI data and machine learning, showing improved accuracy compared to existing atlases.