Spontaneous eye behavior is an objective marker of parkinsonian severity
Ajay K. Verma, Bharadwaj NandakumariD, Quincey FerageniD, Kit Acedillo, Noah Hjelle, Claudia M. Hendrix, Kelly A. DuffyiD, Mark Joseph A. FiecasiD, Ying Yu, Biswaranjan MohantyiD, Jing Wang, Jerrold L. VitekiD, Luke A. JohnsoniD
Abstract
Eye behavior disruption is reported in Parkinson's disease (PD), but its correlation with disease severity has not been well examined. Here, in a nonhuman primate model of PD, we show that spontaneous eye behavior is impaired in parkinsonism and correlates with clinical rating scores and subthalamic beta oscillatory activity. These findings suggest that spontaneous eye behavior could serve as an objective, non-invasive biomarker of parkinsonian severity.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 0
- Organism
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Bilateral Intracranial Beta Activity during Forced and Spontaneous Movements in a Hemi-PD Rat Model
Soheil Mottaghi, Sandra Kohl, … Ulrich Hofmann·Frontiers in NeurosciencePeer-reviewed·Aug 12, 2021
- Preservation of eye movements in Parkinson's disease is stimulus and task specific
Jolande Fooken, Pooja Patel, … Miriam Spering·Journal of NeurosciencePeer-reviewed·Nov 30, 2021
- Reduction of spontaneous cortical beta bursts in Parkinson’s disease is linked to symptom severity
Mikkel C. Vinding, Panagiota Tsitsi, … Daniel Lundqvist·Brain CommunicationsPeer-reviewed·Jan 1, 2020
- Feedback-related potentials and oscillations during trial and error learning in Parkinson's disease
Laura Viñales, Emmanuel Procyk, René Quilodran·bioRxiv·Apr 5, 2021
- Impaired hand dexterity function in a non-human primate model with chronic Parkinson's disease
Jincheol Seo, Jinyoung Won, … Youngjeon Lee·Experimental NeurobiologyPeer-reviewed·Oct 31, 2020
- REM Sleep Disengagement of β Oscillations Permits Rapid Dream Movements in Parkinsonism
Xiaowei Liu, Jing Guang, … Hagai Bergman·bioRxiv·Aug 19, 2026