npj Parkinson s DiseaseNeurosciencePeer-reviewed journal article
Sleep firing rate homeostasis is disrupted in mild parkinsonism
Bharadwaj NandakumariD, Ajay K. Verma, Ying Yu, Ethan Marshall, Adele L. DeNicola, Jing WangiD, Colum D. MacKinnoniD, Michael J. HowelliD, Jerrold L. VitekiD, Luke A. JohnsoniD
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Abstract
Sleep-associated downscaling of neuronal firing, i.e., firing rate homeostasis (FRH), is essential for restorative sleep. Sleep dysfunction is common in Parkinsons disease (PD), but FRH has not been investigated. Here, using a within-subject design in the nonhuman primate model of PD, we report that thalamocortical FRH is disrupted in parkinsonism. These findings can inform therapeutic approaches tailored towards normalizing FRH to reestablish restorative sleep in PD.
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