Luke A. Johnson

This paper develops a computational model of the parkinsonian subthalamic nucleus showing how synchronized bursting produces beta-HFO coupling and explains HFO frequency shifts.

This paper introduces a fast generalized LFPCA method for analyzing longitudinal functional data, showing it is faster and scalable while applied to neuronal firing rate data under DBS.

The paper shows that spontaneous eye behavior in a nonhuman primate PD model correlates with disease severity and beta oscillatory activity, suggesting it as a potential biomarker.

This study investigates how parkinsonism alters population-level neural activity in M1 during movement, finding increased dimensionality and reduced orthogonality between preparatory and movement-related subspaces.

The paper investigates sleep firing rate homeostasis in a nonhuman primate model of Parkinson's disease and finds it is disrupted in parkinsonism.

This study investigates how tACS affects neural entrainment in a primate model of Parkinson's disease, finding that it can both disrupt and reestablish beta-band oscillations depending on stimulation parameters.

This study examines how parkinsonism affects neuronal activity in the pre-SMA during movement preparation in non-human primates, finding disrupted modulation and reduced predictive encoding of reaction time.

This study examines how neuronal activity in the dorsolateral prefrontal cortex changes in parkinsonism using nonhuman primates and finds early impairment in task-related firing rates.

The paper links excessive cortical beta oscillations to slow-wave sleep dysfunction in mild parkinsonism using a nonhuman primate model.

This study examines the role of the basal ganglia in REM sleep movements in Parkinson's disease, finding distinct oscillatory patterns compared to awake movements.

This study demonstrates real-time control of pallidal oscillations in Parkinson's disease using evoked interference deep brain stimulation (eiDBS) to suppress or amplify beta band activity.

The paper uses ECAP features to classify electrode locations in the STN and surrounding regions to improve DBS therapy for Parkinson's disease.

This study identifies high-frequency oscillations in the internal globus pallidus as a pathophysiological feature of Parkinson's disease using clinical and preclinical data.

This study develops a closed-loop neural control framework to suppress or amplify specific low-frequency oscillations in real-time using electrical stimulation in nonhuman primates.

This study shows that transcranial alternating current stimulation (TACS) modulates spike timing in awake nonhuman primates in a dose-dependent manner, with higher intensities increasing neuronal entrainment.