Vladimir V. Lupashin

This study maps the molecular organization of Golgi CATCHR complexes and identifies their roles in vesicle tethering and fusion.

The paper characterizes intra-Golgi trafficking intermediates by analyzing proteomic profiles of Golgi-derived vesicles under COG complex dysfunction, revealing COG-dependent recycling of glycosylation machinery.

This study shows that acute GARP depletion causes vesicle transport defects, leading to mislocalization of Golgi proteins, O-glycosylation issues, and accumulation of vesicle-like structures.

This study shows that Golgi-dependent copper homeostasis, mediated by ATP7 and COG, is essential for maintaining mitochondrial function and synaptic integrity in neurons.