Author

Alexandra L. Howell

Dartmouth CollegeORCID 0000-0002-2362-2596Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Alexandra L. Howell1 paper · Cardiff University

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

David A. ArmstrongiD· 3 shared Christine A. Hodge· 2 shared Matthew S. HaydeniD· 2 shared Anne Gatewood HoeniD· 1 shared Brock C. ChristenseniD· 1 shared Caitlin G. HoweiD· 1 shared Fred KollingiD· 1 shared Hannah E. LaueiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

David A. ArmstrongORCID

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3 papers

Recent·Most cited

Developmental BiologyRNA BiologyPeer-reviewedFeb 20, 2026

Optimizing Protocols for MicroRNA Profiling of Infant and Toddler Stool

David A. Armstrong, Shannon M. Soucy, Meghan E. Muse…·Caitlin G. Howe

This study compares RNA extraction and preservation protocols for miRNA profiling in infant and toddler stool, finding that RNAlater and Zymo DNA/RNA Shield yield similar high-quality RNA with comparable human miRNA profiles.

DOI 10.1080/15476286.2026.2634198

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintJul 8, 2025

Enhanced cleavage of genomic CCR5 using CASX2Max

Christine A. Hodge, Niles P. Donegan, David A. Armstrong…·Alexandra L. Howell

The paper evaluates CasX2Max, a modified CRISPR system, showing it enhances cleavage efficiency for the CCR5 gene compared to native CasX2.

1 citation

humanCRISPR screen

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Molecular BiologybioRxivPreprintJan 2, 2023

CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITY

David A. Armstrong, Taylor R. Hudson, Christine A. Hodge…·Matthew S. Hayden

The paper investigates PlmCas12e cleavage activity on CCR5 by analyzing guide RNA length and PAM sequence variations, identifying optimal conditions for efficient cleavage.

2 citations

humanDNA methylation

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