Synthetic BiologyCellPeer-reviewed
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Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast
Daniel Schindler, Roy S. K. Walker, Shuangying Jiang…·Yizhi Cai
A de novo yeast neochromosome carrying all 275 tRNA genes was built and characterized; it imposes a growth burden, with genome doubling and deletions in haploids possibly reflecting compensation.
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