Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast
Daniel Schindler, Roy S. K. Walker, Shuangying Jiang, Aaron N. Brooks, Yun Wang, Carolin A. Müller, Charlotte A. Cockram, Yisha Luo, Alicia García, Daniel Schraivogel, Julien Mozziconacci, Noah Peña, Mahdi Assari, María del Carmen Sánchez Olmos, Yu Zhao, , Yizhi Cai
A de novo yeast neochromosome carrying all 275 tRNA genes was built and characterized; it imposes a growth burden, with genome doubling and deletions in haploids possibly reflecting compensation.
Cell · Nov 1, 2023Peer-reviewedSynthetic Biology✦ In-depth digest