Le Chen

This study identifies APOH as a promoter of aortic dissection by activating the NR5A1-PPARγ pathway in vascular smooth muscle cells, leading to phenotypic switching and inflammation.

MacaSurfer provides a unified framework for automated surface-volume mapping of the macaque brain across age and sites, showing high consistency and robustness.

This paper introduces STAMO, a spatially aware integration method for unpaired spatial multi-omics data, showing improved alignment and domain detection compared to existing methods.

This paper identifies two circular RNA aptamers that act as sub-stoichiometric chaperones to suppress pathological TDP-43 condensation and rescue splicing and motor dysfunction in vivo.

UcTCRp profiles MAIT- and iNKT-associated immune states using TCRβ sequences without requiring single-cell data or antigen-specific markers.

The paper uses scRNA-seq to analyze T-cell subtypes in Kawasaki disease, identifying a Th17 differentiation bias regulated by the STAT3/JAK axis during acute inflammation.

This paper introduces a compact two-photon imaging module that enables simultaneous dual-depth, multi-region in vivo brain imaging, revealing context-dependent and depth-divergent neural activity patterns.