Author

H B Wu

Center for Excellence in Molecular Cell ScienceORCID 0000-0002-0721-9596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Baomei Cai· 1 shared Bo-Wen Jiang· 1 shared Cong LiuiD· 1 shared Duanqing PeiiD· 1 shared Fang Nan· 1 shared G XuiD· 1 shared Hu SiD· 1 shared Huan Chen· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Baomei Cai

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2 papers

Recent·Most cited

SP2 impedes the pluripotent-to-totipotent state transition in an RA-dependent manner

Hu S, Pinghui Zhu, Liu H, Huan Chen, Shunlan Xu, 郭恩静, Baomei Cai, Xiongzhi Quan, Duanqing Pei, J S Chen, H B Wu, Shangtao Cao

This study identifies SP2 as a barrier to the pluripotency-to-totipotency transition in mouse embryonic stem cells, showing its role in promoting alternative developmental programs.

bioRxiv · Oct 12, 2026 · PreprintDevelopmental Biology

Circular RNA aptamers as superb sub-stoichiometric chaperones of TDP-43 condensation

H B Wu, Peng-Fei Luan, Jiaojiao Hu, Fang Nan, Li Li, Yu-Yin Pan, Bo-Wen Jiang, Jiewen Chen, Xiao Wang, Jiaquan Liu, G Xu, Cong Liu, Le Chen

This paper identifies two circular RNA aptamers that act as sub-stoichiometric chaperones to suppress pathological TDP-43 condensation and rescue splicing and motor dysfunction in vivo.

bioRxiv · Jun 2, 2026 · PreprintMolecular Biology