Author

Jonathan P. Kastan

Cold Spring Harbor LaboratoryORCID 0000-0001-6454-825XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

David Arthur TuvesoniD· 1 shared Dexter W. Adams· 1 shared Douglas T. FearoniD· 1 shared Francesca MinicozziiD· 1 shared Jung‐In YangiD· 1 shared Paolo CifaniiD· 1 shared Philip MorescoiD· 1 shared Rishvanth K. PrabakariD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

David Arthur TuvesonORCID

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1 paper

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 1, 2025

Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells

Philip Moresco, Jonathan P. Kastan, Jung‐In Yang…·Douglas T. Fearon

This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.

8 citations

humanproteomics

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