Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewed
The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias
Meng-Hua M. Tsai, Li Chen, Michael H. Baumann…·Lei Shi
This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.