VAMP7-dependent mitochondria-lysosome contacts regulate glial mitochondrial dynamics and dopaminergic neuron survival
Honglei Wang, Mengxiao Wang, Yu-ting Tsai, Yi-Hsuan Cheng, Yi‐Cheng Lin, C Y Lin, Yi-Hua Lee, Linfang Wang, Shuanglong Yi, Shiping Zhang, Yufeng Pan, Margaret Su-chun Ho
This study shows that VAMP7 regulates mitochondrial-lysosome contacts in fly glia, affecting mitochondrial dynamics and dopaminergic neuron survival through Rab7 GTP hydrolysis.
Proceedings of the National Academy of Sciences · Jul 24, 2026Peer-reviewedNeuroscience