Daniel León-Periñán

Spatiotemporal dynamics of tumor microenvironment remodelling

This study uses spatial transcriptomics to analyze tumor microenvironment remodeling dynamics in triple-negative breast cancer, identifying early stromal programs as potential therapeutic targets.

Scalable image-based visualization and alignment of spatial transcriptomics datasets

The paper introduces STIM, a framework for visualizing and aligning spatial transcriptomics data, demonstrating its use on mouse and human tissue samples.

Open-ST: High-resolution spatial transcriptomics in 3D

Open-ST provides a high-resolution, 3D spatial transcriptomics method to study tissue molecular organization, revealing spatially contiguous structures and biomarkers in tumors and lymph nodes.

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

This study shows that cellular senescence promotes progenitor cell expansion during axolotl limb regeneration by creating a pro-proliferative niche and modulating Wnt signaling.

High-resolution molecular atlas of a lung tumor in 3D

This paper presents a 3D spatial atlas of a human lung carcinoma, revealing tumor microenvironment niches and their associated immune interactions and survival outcomes.