Lisa R. Knoke

This paper identifies RcrB as a detoxification system in uropathogenic Escherichia coli that protects against reactive chlorine species like HOCl by reducing extracellular HOCl and maintaining redox homeostasis.

This study identifies the ABC transporters Gsi and Opp as essential for glutathione import into E. coli, with Gsi specifically required for oxidized glutathione uptake.

The paper shows HOCl forms lipid N-chloramines in bacterial and immune cell membranes, which oxidize proteins and are neutralized by glutathione, suggesting a role in inflammation and immune response.